Curriculum vitae

Career summary

I am an epidemiologist and nutrition scientist investigating how dietary sweeteners—from sugar-containing foods to low-calorie sweeteners and natural sweeteners like honey—shape the risk of obesity, diabetes, and cardiovascular disease. My work synthesizes evidence from published nutrition studies through systematic reviews and meta-analyses using both established and innovative methods, including GRADE assessments, substitution/change analyses, pattern-mixture models, network meta-analysis, and non-linear dose–response modelling. As the methodological lead in our laboratory, I design statistical frameworks for clinical trials and train graduate students to produce high-impact publications. My research has directly informed the dietary guidelines of Diabetes Canada, the Canadian Cardiovascular Society, and the European Association for the Study of Diabetes (EASD).

Education

• PhD, Epidemiology2007–2012
  London School of Hygiene & Tropical Medicine, UK
  Instrumental analysis of genetic variants to assess the role of lipids with stroke risk. Supervisor: Prof. Juan Pablo-Casas
• MSc, Epidemiology2006–2007
  London School of Hygiene & Tropical Medicine, UK
• MBBS (Bachelor of Medicine, Bachelor of Surgery)1996–2001
  Aga Khan University, Karachi, Pakistan

Professional experience

• Lead developer, Toronto 3D AI-Assisted Nutrition Evidence Synthesis Workflow, 2026–present.
  Designing a human-gated, auditable system for systematic reviews and meta-analyses of dietary interventions and nutritional exposures, integrating nutrition-specific comparator and energy-control classification, source verification, reproducible R analysis, GRADE, clinical-importance thresholds and provenance tracking.
• Senior Research AssociateMar 2020–Present
  Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto
  Methodological lead for systematic reviews, meta-analyses, and clinical trials. Supervise 5–7 graduate students annually.
• Post-doctoral FellowJul 2015–Mar 2020
  Department of Nutritional Sciences, University of Toronto
  Method development in systematic reviews and meta-analyses of fructose-containing foods and low-calorie sweeteners. Supervisor: Prof. John Sievenpiper
• Senior Research AssociateNov 2012–Jul 2015
  Vascular Physiology Unit, Institute of Cardiovascular Science, University College London
  Epidemiological and statistical support for trials and cohorts assessing obesity and cardiovascular phenotype in adolescents.
• Research FellowJan 2005–Aug 2006
  Aga Khan University, Karachi, Pakistan
  Supervisor for a Bill & Melinda Gates Foundation funded cluster randomized trial of zinc with micronutrient intervention in Sindh, Pakistan.
• Medical House Officer (Paediatrics)Jan 2004–Dec 2005
  National Institute of Child Health, Karachi, Pakistan
• Research AssistantSep 2002–Jan 2004
  Aga Khan University, Karachi, Pakistan
  Vaccine-preventable childhood diseases in Pakistan.

Awards and honours

• Applied Physiology, Nutrition, and Metabolism Award for Nutrition Translation2025
  Canadian Nutrition Society
• Toronto 3D Post-doctoral Scholarship2021
• Rising Star Award in Research2019
  Unity Health (St Michael's Hospital)
• Clinical Research Award2019
  For outstanding published scientific manuscript with direct clinical relevance (Lancet Diabetes & Endocrinology)
• Toronto 3D Post-doctoral Scholarship2018
• Rank Prize Fund Travel Award2017
• Graduate Teaching PhD Scholarship2008

Research funding

Obtained ~$1.5 million CAD on grants led and submitted as Acting Principal Applicant (API) with the permission of lab Chair John Sievenpiper (PI). University of Toronto policies prevent a research associate from applying as Principal Applicant.

• $450,000 CAD2025–2028
  Diabetes Canada End-Diabetes Award
  Non-Sugar Sweeteners and Type 2 Diabetes: A Mega-Cohort Pooling Project to Strengthen Causal Inference. Sievenpiper JL, Khan TA.
• $150,000 USD2023–2025
  Fruit Juice Science Centre
  Substitution of pure fruit juice for sugar-sweetened beverages and cardiometabolic disease risk in the EPIC Cohort. Sievenpiper JL, Khan TA.
• $96,800 USD2022–2023
  National Honey Board USA (USDA Checkoff)
  Compositional analysis of honey: supplemental analysis of US floral honeys. Sievenpiper JL, Kendall C, Cao R, Cui S, Khan TA. [Wrote proposal, submitted on behalf of PI]
• $90,000 USD2020–2022
  IAFNS (formerly ILSI North America)
  Systematic Review and Network Meta-Analyses of Low-Calorie Sweeteners and Glycemic Response. Sievenpiper JL, Khan TA, Kendall C. [Wrote full proposal]
• $250,000 USD2020–2022
  National Honey Board USA (USDA Checkoff)
  Compositional analysis of honey with a focus on rare sugars. Sievenpiper JL, Kendall C, Cao R, Cui S, Khan TA. [Initiated collaboration, wrote full proposal]
• $22,000 USD2019–2021
  ILSI North America
  Metabolic and physiological properties of rare sugars. Sievenpiper JL, Khan TA. [Wrote full proposal]
• $300,000 CAD2017–2022
  Canadian Institutes of Health Research (CIHR)
  STOP SUGARS NOW Trial: RCT of replacing sugar-sweetened beverages with non-nutritive sweetened beverages or water on gut microbiome and metabolic outcomes. Sievenpiper JL, Comelli E, Khan TA. [Co-conceived idea, wrote full proposal]
• $3,750 CAD
  Bee Maid Honey Limited Canada
  Effect of honey on cardiometabolic risk: systematic review and meta-analyses. Sievenpiper JL, Khan TA. [Conceived idea, wrote grant]

Peer-reviewed publications (101)

1. Erlich MN, Ghidanac D, Blanco Mejia S, Ayoub-Charette S, Vittes Combe C, Khan TA, Ramdath D, Crewson H, Beck A, Silva C, Ramdath DD, Metherel AH, Bazinet RP, Leiter LA, Kendall CWC, Jenkins DJA, Chiavaroli L, Sievenpiper JL. Rationale, Design, and Participant Baseline Characteristics of the Soy Treatment Evaluation for Metabolic Health (STEM) Trial. Nutrients. 2026;18:1026. doi:10.3390/nu18071026
2. Shyam S, Ayoub-Charette S, Khandpur N, Kavanagh ME, Khan TA (corresponding author). Plant-based meat alternatives: understanding the benefits and trade-offs for human and environmental health. Eur J Clin Nutr. 2026. doi:10.1038/s41430-026-01725-2
3. Ayoub-Charette S, Nguyen M, Chiavaroli L, Mattes RD, de Souza RJ, Khan TA, Higgins KA, Saxena N, MacKay D, Panahi S, Sievenpiper JL, Malik VS. Low- and no-calorie sweeteners and health: unravelling the evidence and controversy. Appl Physiol Nutr Metab. 2026;51:1-11. doi:10.1139/apnm-2025-0440
4. Ayoub-Charette S, Kavanagh M, Khan TA, Sievenpiper JL. Reconciling Conflicting Evidence on Low- and No-Calorie Sweeteners and Cardiometabolic Outcomes: An Umbrella Review Using Naïve and Bias-Adjusted Methods. Appl Physiol Nutr Metab. 2025; ahead of print. doi:10.1139/apnm-2025-0068
5. Khan TA, Ayoub-Charette S, Shyam S. Structural funding bias in red meat research: The elephant in the room. Am J Clin Nutr. 2025 Aug 9:S0002-9165. doi:10.1016/j.ajcnut.2025.08.001
6. Semnani-Azad Z, Khan TA, Chiavaroli L, et al. Intermittent fasting strategies and their effects on body weight and other cardiometabolic risk factors: systematic review and network meta-analysis of randomised clinical trials. BMJ. 2025;389. doi:10.1136/bmj-2024-082007
7. Ayoub-Charette S, McGlynn N, Lee D, Khan TA, et al. Non-nutritive-Sweetened Beverages Are Similar to Water in SSBs Reduction: STOP Sugars NOW Trial. Curr Dev Nutr. 2025;9.
8. Viscardi G, Back S, Ahmed A, Yang S, Mejia SB, Zurbau A, Khan TA, Selk A, Messina M, Kendall CW, Jenkins DJ. Effect of soy isoflavones on measures of estrogenicity: a systematic review and meta-analysis of randomized controlled trials. Adv Nutr. 2025;16(1):100327. doi:10.1016/j.advnut.2024.100327
9. Zhu Y, Liu R, Mats L, Zhu H, Khan T, et al. Antioxidant and anti-inflammatory activities of major phenolics from selected floral honeys. J Food Bioact. 2024;28. doi:10.26599/JFB.2024.95028398
10. Khan TA, Ayoub-Charette S, Sievenpiper JL. Non-nutritive Sweeteners and Health: Reconciling Evidence and Interrogating Guideline Disconnects. Adv Nutr. 2024;15(12). doi:10.1016/j.advnut.2024.100328
11. Erlich MN, Ghidanac D, Blanco Mejia S, Khan TA, et al. Substituting soymilk for cow's milk and intermediate cardiometabolic outcomes: systematic review and meta-analysis. BMC Med. 2024;22(1):336. doi:10.1186/s12916-024-03524-7
12. Ayoub-Charette S, Khan TA, et al. Lack of Biological Plausibility and Major Methodological Issues Cast Doubt on the Association between Aspartame and Autism. Nutrients. 2024;16(5):675. doi:10.3390/nu16050675
13. Jenkins DJ, Willett WC, Yusuf S, Hu FB, Glenn AJ, Liu S, ... Khan TA et al. Association of glycaemic index and glycaemic load with type 2 diabetes, cardiovascular disease, cancer, and all-cause mortality. Lancet Diabetes Endocrinol. 2024;12(2):107-18. doi:10.1016/S2213-8587(23)00344-3
14. Noronha JC, Nishi SK, Khan TA, et al. Weight management using meal replacements and cardiometabolic risk reduction in pre-diabetes/metabolic syndrome: systematic review and meta-analysis of RCTs. Obes Rev. 2024;e13751. doi:10.1111/obr.13751
15. Nguyen M, Jarvis SE, Chiavaroli L, Mejia SB, Zurbau A, Khan TA, et al. Consumption of 100% Fruit Juice and Body Weight in Children and Adults: Systematic Review and Meta-Analysis. JAMA Pediatr. 2024 Jan 16. doi:10.1001/jamapediatrics.2023.6124
16. Siu T, sahye-pudaruth S, Mannan F, et al. ...Khan T, Kendall C. Association of Serum TMAO Levels With Cardiovascular Disease and All-Cause Mortality: Systematic Review and Dose-Response Meta-Analysis. Circulation. 2023;148(Suppl 1):A13681.
17. Chen V, Khan TA, Chiavaroli L, et al. Response to comment on "Relation of fruit juice with adiposity and diabetes depends on how fruit juice is defined." Eur J Clin Nutr. 2023;77(12):1178-9. doi:10.1038/s41430-023-01323-6
18. Zurbau A, Khan TA, Wolever TM, Sievenpiper JL. Unveiling the optimal soluble dietary fiber for type 2 diabetes: galactomannans take the lead? Am J Clin Nutr. 2023;118(4):834-6. doi:10.1016/j.ajcnut.2023.06.021
19. Khan TA, Lee JJ, Ayoub-Charette S, et al. WHO guideline on the use of non-sugar sweeteners: a need for reconsideration. Eur J Clin Nutr. 2023;77(11):1009-13. doi:10.1038/s41430-023-01314-7
20. DNSG of the EASD. Evidence-based European recommendations for the dietary management of diabetes. Diabetologia. 2023:1-21. [Writing group member: low-calorie sweetener and low-risk lifestyle recommendations] doi:10.1007/s00125-023-05894-8
21. Lee JJ, Khan T, Sievenpiper JL. Response to Comment on Lee et al. Diabetes Care. 2023;46(4):e99-100. doi:10.2337/dci22-0051
22. Ayoub-Charette S, McGlynn ND, Lee D, Khan TA, et al. Rationale, Design and Participants Baseline Characteristics: STOP Sugars NOW Trial. Nutrients. 2023;15(5):1238. doi:10.3390/nu15051238
23. Khan TA, Field D, Chen V, et al. Combination of Multiple Low-Risk Lifestyle Behaviors and Incident Type 2 Diabetes: Systematic Review and Dose-Response Meta-analysis. Diabetes Care. 2023;46(3):643-56. doi:10.2337/dc22-1024
24. Zhang R, Noronha JC, Khan TA, et al. Effect of Non-Nutritive Sweetened Beverages on Postprandial Glycemic and Endocrine Responses: Systematic Review and Network Meta-Analysis. Nutrients. 2023;15(4):1050. doi:10.3390/nu15041050
25. Chiavaroli L, Cheung A, Ayoub-Charette S, ...Khan T. Important food sources of fructose-containing sugars and adiposity: systematic review and meta-analysis of controlled feeding trials. Am J Clin Nutr. 2023 Feb 23. doi:10.1016/j.ajcnut.2023.01.023
26. Nasser SM, Rana AA, Doffinger R, Kafizas A, Khan TA, Nasser S. Elevated free interleukin-18 associated with severity and mortality in COVID-19 patients. Intensive Care Med Exp. 2023;11(1):1-9. doi:10.1186/s40635-022-00488-x
27. Chen V, Khan TA, Chiavaroli L, et al. Relation of fruit juice with adiposity and diabetes depends on how fruit juice is defined. Eur J Clin Nutr. 2023;77(7):699-704. doi:10.1038/s41430-023-01258-y
28. Nguyen M, Jarvis SE, Tinajero MG, ... Khan TA, et al. Sugar-sweetened beverage consumption and weight gain: systematic review and meta-analysis. Am J Clin Nutr. 2022 Dec 20. doi:10.1016/j.ajcnut.2022.11.008
29. Ahmed A, Tul-Noor Z, Lee D, ... Khan TA (corresponding author), Sievenpiper JL. Effect of honey on cardiometabolic risk factors: systematic review and meta-analysis. Nutr Rev. 2022 Nov. doi:10.1093/nutrit/nuac086
30. Almaatani D, Zurbau A, ... Khan TA, Sievenpiper JL, Van Den Heuvel M. Parents' stress and parental feeding practices: systematic review and meta-analysis. Matern Child Nutr. 2022;e13448. doi:10.1111/mcn.13448
31. Yu J, Balaji B, Tinajero M, Jarvis S, Khan T, et al. White rice, brown rice and the risk of type 2 diabetes: systematic review and meta-analysis. BMJ Open. 2022;12(9):e065426. doi:10.1136/bmjopen-2022-065426
32. Qi X, Chiavaroli L, Lee D, ... Khan TA, et al. Important Food Sources of Fructose-Containing Sugars on Inflammatory Biomarkers: Systematic Review and Meta-Analysis. Nutrients. 2022;14(19):3986. doi:10.3390/nu14193986
33. Chen V, Zurbau A, Ahmed A, Khan TA, et al. Effect of oats and oat β-glucan on glycemic control in diabetes: systematic review and meta-analysis of RCTs. BMJ Open Diabetes Res Care. 2022;10(5):e002784. doi:10.1136/bmjdrc-2022-002784
34. Massara P, Zurbau A, Glenn AJ, Chiavaroli L, Khan TA, et al. Nordic dietary patterns and cardiometabolic outcomes: systematic review and meta-analysis. Diabetologia. 2022;65(12):2011-31. doi:10.1007/s00125-022-05760-z
35. Jovanovski E, Nguyen M, ... Khan TA, et al. Viscous vs non-viscous fibre from cereal sources and lipid lowering: systematic review and meta-analysis of RCTs. Br J Nutr. 2022 Aug 5:1-3. doi:10.1017/S0007114522002355
36. Lee JJ, Khan TA, McGlynn N, et al. Relation of Change or Substitution of Low- and No-Calorie Sweetened Beverages With Cardiometabolic Outcomes. Diabetes Care. 2022;45(8):1917-30. doi:10.2337/dc21-2130
37. Lee D, Chiavaroli L, Ayoub-Charette S, Khan TA, et al. Important food sources of fructose-containing sugars and NAFLD: systematic review and meta-analysis. Nutrients. 2022;14(14):2846. doi:10.3390/nu14142846
38. Jayedi A, Khan TA, Aune D, et al. Body fat and risk of all-cause mortality: systematic review and dose-response meta-analysis. Int J Obes. 2022;46(9):1573-81. doi:10.1038/s41366-022-01165-5
39. McGlynn N, Khan T, et al. Effect of Non-Nutritive Sweetened Beverages on Cardiometabolic Risk: Network Meta-Analysis of RCTs. JAMA Netw Open. 2022;5(3):e222092. doi:10.1001/jamanetworkopen.2022.2092
40. Hosseini F, Jayedi A, Khan TA, Shab-Bidar S. Dietary carbohydrate and risk of type 2 diabetes: systematic review and dose-response meta-analysis. Sci Rep. 2022;12(1):2491. doi:10.1038/s41598-022-06212-9
41. Noori M, Jayedi A, Khan TA, et al. Mediterranean dietary pattern and bone mineral density: dose-response meta-analysis. Eur J Clin Nutr. 2022:1-8. doi:10.1038/s41430-022-01093-7
42. Kazemi A, Soltani S, ... Khan T, et al. Major food sources of fructose and cardiovascular disease, cancer, and all-cause mortality: dose-response meta-analysis. Crit Rev Food Sci Nutr. 2021:1-4. doi:10.1080/10408398.2021.2000361
43. Khan TA, Sievenpiper JL, Fernstrom JD. Dietary Glutamic Acid, Obesity, and Depressive Symptoms in Patients With Schizophrenia. Front Psychiatry. 2021;12:725786. doi:10.3389/fpsyt.2021.725786
44. Glenn AJ, Boucher BA, Kavcic CC, Khan TA, et al. Development of a Portfolio Diet Score. Nutrients. 2021;13(8):2850. doi:10.3390/nu13082850
45. Chiavaroli L, Lee D, Ahmed A, ... Khan TA, et al. Low glycaemic index or load dietary patterns on glycaemic control in diabetes: systematic review and meta-analysis. BMJ. 2021;374. doi:10.1136/bmj.n1651
46. Ahmed A, Khan TA, Ramdath D, et al. Rare sugars and their health effects in humans: systematic review and narrative synthesis. Nutr Rev. 2022;80(2):255-70. doi:10.1093/nutrit/nuab012
47. Zurbau A, Noronha JC, Khan TA, et al. Effect of oat β-glucan on postprandial blood glucose and insulin: systematic review and meta-analysis. Eur J Clin Nutr. 2021;75(11):1540-54. doi:10.1038/s41430-021-00875-9
48. Shahinfar H, Jayedi A, Khan TA, et al. Coffee consumption and cardiovascular diseases and mortality in type 2 diabetes: systematic review and dose-response meta-analysis. Nutr Metab Cardiovasc Dis. 2021;31(9):2526-38. doi:10.1016/j.numecd.2021.05.014
49. Jayedi A, Emadi A, Khan TA, et al. Dietary fiber and survival in women with breast cancer: dose-response meta-analysis. Nutr Cancer. 2021;73(9):1570-80. doi:10.1080/01635581.2020.1803928
50. Ayoub-Charette S, Chiavaroli L, ... Khan TA, et al. Food Sources of Fructose-Containing Sugars and Fasting Blood Uric Acid: Systematic Review and Meta-Analysis. J Nutr. 2021 Jun 4. doi:10.1093/jn/nxab144
51. Zeraatkar D, Bhasin A, ... Khan TA, et al. Systematic reviews and meta-analyses of nutritional epidemiology studies often have serious methodological limitations. Am J Clin Nutr. 2021;113(6):1578-92. doi:10.1093/ajcn/nqab002
52. Khan TA, Sievenpiper JL. Low-calorie sweeteners with carbohydrate do not impair insulin sensitivity: Re-analysis highlighting the importance of the comparator. Cell Metab. 2021;33(2):225-6. doi:10.1016/j.cmet.2020.10.024
53. Jovanovski E, Mazhar N, ... Khan T, et al. Viscous fiber supplementation and obesity indicators: systematic review and meta-analysis. Eur J Nutr. 2021;60(1):101-12. doi:10.1007/s00394-020-02224-1
54. Vors C, Allaire J, Mejia SB, Khan TA, Sievenpiper JL, Lamarche B. Letter to the Editor Reply re: DHA and EPA inflammation. Adv Nutr. 2021;12(1):278-9. doi:10.1093/advances/nmaa131
55. Zurbau A, Au-Yeung F, Mejia SB, Khan T. Relation of Different Fruit and Vegetable Sources With Incident Cardiovascular Outcomes. J Am Heart Assoc. 2020;9:e017728. doi:10.1161/JAHA.120.017728
56. Khan TA, Sievenpiper JL. Low-energy sweeteners and cardiometabolic health: is there method in the madness? Am J Clin Nutr. 2020;112(4):917-9. doi:10.1093/ajcn/nqaa260
57. Jayedi A, Soltani S, Zargar MS, Khan TA, Shab-Bidar S. Central fatness and the risk of all-cause mortality: systematic review and dose-response meta-analysis of 72 prospective cohort studies. BMJ. 2020;370. doi:10.1136/bmj.m3324
58. Vors C, Allaire J, Mejia SB, Khan T, et al. Comparing effects of DHA and EPA on inflammation markers using pairwise and network meta-analyses. Adv Nutr. 2020. doi:10.1093/advances/nmaa086
59. Li D, Nishi S, ... Khan T, et al. Nitrate-rich interventions on blood pressure and arterial stiffness: systematic review and meta-analysis. J Hypertens. 2020;38. doi:10.1097/HJH.0000000000002524
60. Semnani-Azad Z, Khan TA, Mejia SB, et al. Food sources of fructose-containing sugars and incident metabolic syndrome: systematic review and meta-analysis. JAMA Netw Open. 2020;3(7):e209993. doi:10.1001/jamanetworkopen.2020.9993
61. Khan TA, Chiavaroli L, Bazinet RP, Sievenpiper JL. Apparent conflicts of interest do not preclude scientific rigor. Am J Clin Nutr. 2020;111(4):915-6. doi:10.1093/ajcn/nqaa005
62. Jovanovski E, Mazhar N, ... Khan T, et al. Viscous fiber and obesity on calorie-restricted diets: systematic review and meta-analysis of RCTs. Eur J Nutr. 2020:1-2. doi:10.1007/s00394-020-02224-1
63. Braunstein CR, Noronha JC, Khan TA, et al. Fructose and its epimers on postprandial carbohydrate metabolism: systematic review and meta-analysis. Clin Nutr. 2020;39(11):3308-18. doi:10.1016/j.clnu.2020.03.002
64. Jovanovski E, Mazhar N, ... Khan T, et al. Dietary viscous fiber and body weight independently of energy restriction: systematic review and meta-analysis. Am J Clin Nutr. 2020 Jan 3. doi:10.1093/ajcn/nqz292
65. Liu Q, Ayoub-Charette S, Khan TA, et al. Food Sources of Fructose-Containing Sugars and Incident Hypertension: Systematic Review and Dose-Response Meta-Analysis. J Am Heart Assoc. 2019;8:e010977. doi:10.1161/JAHA.118.010977
66. Khan TA, Tayyiba M, Agarwal A, et al. Relation of Total Sugars, Sucrose, Fructose, and Added Sugars with CVD Risk: Systematic Review and Dose-response Meta-Analysis. Mayo Clin Proc. 2019:1-16. doi:10.1016/j.mayocp.2019.05.034
67. Khan TA, Chiavaroli L, Zurbau A, Sievenpiper JL. Lack of consideration of a dose-response relationship can lead to erroneous conclusions regarding 100% fruit juice and cardiometabolic disease. Eur J Clin Nutr. 2019:1-5. doi:10.1038/s41430-019-0514-x
68. Viguiliouk E, Glenn AJ, Nishi SK, ... Khan T, et al. Pulses and cardiometabolic disease outcomes: umbrella review and updated systematic review and meta-analysis. Adv Nutr. 2019;00:1-11. doi:10.1093/advances/nmz113
69. Uusitupa M, Khan TA, Viguiliouk E, et al. Prevention of Type 2 Diabetes by Lifestyle Changes: Systematic Review and Meta-Analysis. Nutrients. 2019;11(11):2611. doi:10.3390/nu11112611
70. Glenn AJ, Viguiliouk E, ... Khan TA, et al. Vegetarian dietary patterns and major cardiovascular outcomes: systematic review and meta-analysis. Front Nutr. 2019;6:80. doi:10.3389/fnut.2019.00080
71. Khan TA, Malik VS, Sievenpiper JL. Artificially Sweetened Beverages and Stroke, CHD, and All-Cause Mortality in the Women's Health Initiative. Stroke. 2019;50. doi:10.1161/STROKEAHA.119.025571
72. Ayoub-Charette S, Liu Q, Khan TA, et al. Food sources of fructose-containing sugars and incident gout: systematic review and meta-analysis. BMJ Open. 2019;9:e024171. doi:10.1136/bmjopen-2018-024171
73. Blanco MS, Messina M, ... Khan TA, et al. Soy Protein Decreases Circulating LDL and Total Cholesterol: meta-analysis of 46 studies. J Nutr. 2019 Apr 22. doi:10.1093/jn/nxz020
74. Noronha JC, Nishi SK, Braunstein CR, Khan TA, et al. Liquid meal replacements on cardiometabolic risk in T2D: systematic review and meta-analysis of RCTs. Diabetes Care. 2019;42(5):767-76. doi:10.2337/dc18-2270
75. Becerra-Tomás N, Blanco Mejía S, ... Khan T, et al. Mediterranean diet, cardiovascular disease and mortality in diabetes: systematic review and meta-analysis. Crit Rev Food Sci Nutr. 2019:1-21. doi:10.1080/10408398.2019.1565281
76. Masi S, Georgiopoulos G, Khan T, et al. Patterns of adiposity, vascular phenotypes and cognitive function in the 1946 British Birth Cohort. BMC Med. 2018;16(1):75. doi:10.1186/s12916-018-1059-x
77. D'Aiuto F, Gkranias N, Bhowruth D, Khan T, et al. Systemic effects of periodontitis treatment in patients with T2D: a 12-month RCT. Lancet Diabetes Endocrinol. 2018;6(12):954-65. doi:10.1016/S2213-8587(18)30038-X
78. Braunstein CR, Noronha JC, Glenn AJ, ... Khan TA, et al. Acute Feeding Equivalence Trial of Small Doses of Fructose and Allulose: FACE Trial. Nutrients. 2018;10(6):750. doi:10.3390/nu10060750
79. Wade KH, Chiesa ST, Hughes AD, ... Khan T, et al. Assessing the causal role of BMI on cardiovascular health in young adults: Mendelian randomization. Circulation. 2018;138(20):2187-2201. doi:10.1161/CIRCULATIONAHA.117.033278
80. Chiavaroli L, Nishi SK, Khan TA, et al. Portfolio Dietary Pattern and Cardiovascular Disease: Systematic Review and Meta-Analysis of Controlled Trials. Prog Cardiovasc Dis. 2018 May 26. doi:10.1016/j.pcad.2018.05.004
81. Noronha JC, Braunstein CR, Glenn AJ, Khan TA, et al. Small doses of fructose and allulose on postprandial glucose metabolism in T2D: double-blind RCT. Diabetes Obes Metab. 2018;20(10):2361-70. doi:10.1111/dom.13374
82. Sievenpiper JL, Khan TA, Ha V, Viguiliouk E, Auyeung R. Importance of study design in assessment of non-nutritive sweeteners and cardiometabolic health. CMAJ. 2017;189(46):E1424-5. doi:10.1503/cmaj.733381
83. Choo VL, Viguiliouk E, Blanco Mejia S, ... Khan TA, et al. Food sources of fructose-containing sugars and glycemic control: systematic review and meta-analysis. BMJ. 2018;363:k4644. doi:10.1136/bmj.k4644
84. Tsilas CS, de Souza RJ, ... Khan T, et al. Relation of total sugars, fructose, and sucrose with incident type 2 diabetes: systematic review and meta-analysis. CMAJ. 2017;189(20):E711-720. doi:10.1503/cmaj.160706
85. Khan TA, Sievenpiper JL. Controversies about sugars: results from systematic reviews and meta-analyses on obesity, cardiometabolic disease and diabetes. Eur J Nutr. 2016;55(Suppl 2):25-43. doi:10.1007/s00394-016-1345-3
86. Jamnik J, Rehman S, ... Khan TA, et al. Fructose Intake and Risk of Gout and Hyperuricemia: Systematic Review and Meta-Analysis. BMJ Open. 2016;6(10):e013191. doi:10.1136/bmjopen-2016-013191
87. Khan TA, Sievenpiper JL. Metabolic Improvement with Fructose Restriction: Is It the Fructose or the Weight Loss? Obesity. 2016;24(3):549. doi:10.1002/oby.21431
88. O'Neill F, McLoughlin E, ... Khan T, et al. Reproducibility and Biological Variability of HDL's Vascular Functional Assays. Atherosclerosis. 2015;241(2):588-94. doi:10.1016/j.atherosclerosis.2015.06.005
89. Hudson LD, Rapala A, Khan T, et al. Arterial stiffening in obese children and adolescents using pulse wave velocity: systematic review and meta-analysis. Atherosclerosis. 2015;241(2):376-86. doi:10.1016/j.atherosclerosis.2015.05.014
90. O'Neill F, Riwanto M, ... Khan T, et al. Structural and functional changes in HDL with low grade and chronic inflammation. Int J Cardiol. 2015;188:111-6. doi:10.1016/j.ijcard.2015.03.058
91. Masi S, D'Aiuto F, Martin-Ruiz C, Khan T, et al. Rate of Telomere Shortening and Cardiovascular Damage: A Longitudinal Study. Eur Heart J. 2014;35(46):3296-3303. doi:10.1093/eurheartj/ehu226
92. Charakida M, Khan T, Johnson W, et al. Lifelong Patterns of BMI and Cardiovascular Phenotype at ages 60–64 in the 1946 British Birth Cohort. Lancet Diabetes Endocrinol. 2014;2(8):648-54. doi:10.1016/S2213-8587(14)70103-2
93. Charakida M, de Groot E, Loukogeorgakis SP, Khan T, et al. Variability and Reproducibility of Flow-Mediated Dilatation. Eur Heart J. 2013;34(45):3501-7. doi:10.1093/eurheartj/eht223
94. Khan TA, Shah T, Prieto D, et al. Apolipoprotein E genotype, cardiovascular biomarkers and risk of stroke: Systematic review and meta-analysis of 14,015 stroke cases. Int J Epidemiol. 2013;42(2):475-92. doi:10.1093/ije/dyt034
95. Charakida M, Jones A, Falaschetti E, Khan TA, et al. Vascular adaption to obesity in Childhood. J Am Coll Cardiol. 2012;60(25):2643-50. doi:10.1016/j.jacc.2012.08.1017
96. Holmes MV, Shah SH, Angelakopoulou A, Khan TA, et al. Complex disease genetics: present and future translational applications. Genome Med. 2009;1(11):104. doi:10.1186/gm104
97. Zaidi AKM, Thaver D, Ali SA, Khan TA. Pathogens associated with sepsis in newborns and young infants. Pediatr Infect Dis J. 2009;28(1 Suppl):S10-8. doi:10.1097/INF.0b013e3181958769
98. Khan TA, Madni SA, Zaidi AKM. Acute respiratory infections in Pakistan: have we made any progress? J Coll Physicians Surg Pak. 2004;14(7):440-448.
99. Khurram IM, Khan SA, ... Khan TA. Risk factors for clinical infection in patients colonized with MRSA. JPMA. 2004;54(8):408-12.
100. Khan TA, Zaidi AKM. Vaccine-Preventable Childhood Diseases in Pakistan – A Situational Analysis. J Infect Dis Pak. 2003;12(2):49-56.
101. Ali SA, Khan TA, Zaidi AKM. Neonatal sepsis in Peshawar. Arch Dis Child Fetal Neonatal Ed. 2002;87(3):F233. doi:10.1136/fn.87.3.F233-a

Other publications

Preprint

• Jayedi A, Khan TA, Mirrafiei A, et al. Dose-dependent effect of nuts on blood pressure: systematic review and meta-analysis of RCTs. medRxiv. 2021.

Book chapters

• Khan TA, Ayoub-Charette S, Sievenpiper JL, Comelli EM. Non-Nutritive Sweeteners and Their Effects on Human Health and the Gut Microbiome. Encyclopedia of Gastroenterology. Elsevier; 2019.
• Ayoub-Charette S, López-Domínguez L, Khan TA, Sievenpiper JL, Comelli EM. Dietary Emulsifiers and their Effects on the Gut Microbiome. Encyclopedia of Gastroenterology, 2nd Ed. 2019.
• Khan TA. 'HONEYBEE' in A. Walker, C. Fitzpatrick (ed.), Muhammad in History, Thought, and Culture: An Encyclopedia of the Prophet of God, ABC-CLIO. 2013.

Books

• Iqbal F, Khan TA. Understanding Islam: Dispelling myths about Jihad, Oppression and Violence in Islam. Ahmadiyya Muslim Community; 2018. 158 pages.

Reports

• Turner K, Khan T, Kirkwood B. A Review of the Effectiveness of Supplementary Feeding Strategies. MAINSTREAMING NUTRITION IN MATERNAL CHILD HEALTH. The World Bank. 2007.
• Khan TA, Zaidi AKM. Indoor Air Pollution and Child Health in Pakistan. World Health Organization. 2005.
• Zaidi AKM, Khan TA, Akram DS. Early Child Health and Survival Strategies in Pakistan. In: Bhutta ZA (ed). Maternal and Child Health in Pakistan. Oxford University Press. 2003.
• Khan T, Hussain M. National Nutrition programmes and projects of Pakistan. Report for Government of Pakistan and UNICEF. 2003.

Thesis

• Khan TA. Using Lipid Gene Variants as Instruments to Dissect Biological Pathways. PhD Thesis. London School of Hygiene & Tropical Medicine. 2012.

Invited presentations

• Sweet Choices, Serious Consequences: Navigating Added Sugars, Low- and No-Calorie Sweeteners in Oral & Overall Healthcare. American Dental Association (ADA) Annual Meeting, Indianapolis, IN.Oct 2026 (forthcoming)
• Low- and No-Calorie Sweeteners: Reconciling Evidence, Guidelines, and New Directions. IAFNS Food Classification Research Roundtable: Processing, Formulation, and Nutrition, Washington, DC.Mar 2026
• Rare sugars and honey and small quantities of sugars to promote healthy foods consumption. 6th ICQC Meeting, Kalamata, Greece.Oct 2025
• Updates on a mega-cohorts pooling project for low- and no-calorie sweeteners and health outcomes. 6th ICQC Meeting, Kalamata, Greece.Oct 2025
• Systematic overview of global guidelines for low- and no-calorie sweeteners. 6th ICQC Meeting, Kalamata, Greece.Oct 2025
• Low and no calorie sweeteners as a tool for sugars reduction: Moving from evidence to harmonized guidelines. 42nd DNSG meeting, Ottawa, Canada.Jun 2025
• Low- and no-calorie sweeteners and health: Current evidence and path forward. CNS Webinar.Apr 2025
• Low-Calorie Sweeteners: Health Evidence and Nutritional Guidance. International Nutrition and Health Symposium, Dubai.Sep 2024
• The Health Benefits of Maple Syrup: the role of rare sugars. Ontario Maple Syrup Association, North Bay, Ontario.Jul 2024
• Interpretation, Inference and Future Directions: Panel Discussion on Observational Studies. ASN Conference, Chicago.2024
• Non-nutritive sweeteners and health: Reconciling the evidence. CNS Thematic Conference, Toronto.Jan 2024
• Synthesis of evidence on Low and non-caloric sweeteners, body weight and other health effects. DIFSC Dubai Food Conference.Dec 2023
• Recommendations and regulation on low/no calorie sweeteners: Global and Brazilian perspectives. ISA-SBAN Webinar.Dec 2023
• The effect of floral honey on health and honey rare sugars. Alberta Beekeepers AGM, Edmonton.Nov 2023
• Evidence basis for WHO guideline on non-sugar sweeteners. Reformulation of Food Products Conference, Ankara, Turkey.Jun 2023
• Navigating the WHO guideline on non-sugar sweeteners. DNSG, Pula, Croatia.Jun 2023
• International guidelines on non-sugar sweeteners and health. Food Additive Summit, Muscat, Oman.May 2023
• Evidence on low- and non-calorie sweeteners: The WHO guideline and reconsideration. GCC Standardization workshop, Riyadh, Saudi Arabia.Mar 2023
• Low-calorie sweeteners on acute metabolic risk factors: updated evidence. IAFNS press briefing (virtual).Feb 2022
• WHO's 2022 Draft Guidelines on Non-Sugar Sweeteners. IAFNS/IFIC/CCC Seminar (virtual).Aug 2022
• The role of food sources of sugars and non-caloric sweeteners on cardiometabolic disease. CCC Annual Meeting, Washington DC.Nov 2018
• Apolipoprotein E Genotype and ischaemic stroke. Cambridge Strangeways Laboratory.2010

Conference session chair

• Co-Chair, Session 16 — Short Oral Abstracts. 43rd International Symposium on Diabetes & Nutrition (DNSG/EASD), Montbrió de Camp, Tarragona, Spain.Jun 2026
  Co-chaired with Stephanie Nishi (17 June 2026).

Conference abstracts

Selected first author

• Khan TA, Ahmad S, Ayoub-Charette S, et al. Substitution of Low- and No-Calorie Sweetened Beverages for Sugar-Sweetened Beverages and Cardiometabolic Outcomes: A Systematic Review and Meta-substitution Analysis of Mega-Cohort Studies of ≥100,000 participants. 43rd International Symposium on Diabetes & Nutrition (DNSG/EASD), Montbrió de Camp, Tarragona, Spain, 15 Jun 2026. Short Oral (SO14), Session 7.
• Khan TA, et al. Effect of rare sugars on cardiometabolic outcomes: systematic review and meta-analysis. Rare Sugar Congress, Takamatsu, Japan, Mar–Apr 2023. Poster.
• Khan TA, et al. Important food sources of sugars and type 2 diabetes: systematic review and meta-analysis. Diabetes Canada Conference, Calgary, Nov 2022. Poster.
• Khan TA, et al. Important food sources of sugars and type 2 diabetes. 39th DNSG/EASD International Symposium, Athens, Greece, Jun 2022. Oral.
• Khan TA, et al. Effect of intermittent fasting strategies on cardiometabolic risk factors: network meta-analysis of RCTs. 38th DNSG/EASD Symposium, Spain (virtual), Jun 2021. Poster.
• Khan TA, et al. Effect of intermittent fasting strategies: network meta-analysis of RCTs. CNS Thematic Conference, Jan 2021. Poster.
• Khan TA, et al. Important food sources of sugars and type 2 diabetes. CNS, Niagara Falls, Canada, May 2019. Poster.
• Khan TA, et al. Important food sources of sugars and type 2 diabetes. 36th DNSG/EASD Symposium, Opatija, Croatia, Jun 2018. Oral.
• Khan TA, et al. Important Food Sources of Sugars and Type 2 Diabetes. Diabetes Canada Conference, Halifax, 2018. Poster.
• Khan TA, et al. Low-risk lifestyle behaviours and diabetes. CIHR INMD Meeting, Toronto, 2018. Poster.
• Khan TA, et al. The effect of honey intake on lipid risk factors. Rank Prize Fund Mini-symposium, Grasmere, UK, 2017. Oral.
• Khan TA, et al. Low-risk lifestyle behaviours and incident type 2 diabetes. 35th DNSG/EASD Symposium, Skagen, Denmark, Jun 2017. Poster.
• Khan TA, et al. Relation of Fructose-Containing Sugars with CVD. ASN/EB, Chicago, 2017. Poster.
• Khan TA, et al. Honey consumption and cardiometabolic risk. Tahir Heart Institute Conference, Rabwah, Pakistan, 2016. Oral.
• Khan TA, et al. Low risk lifestyle behaviours and CV Events. 34th DNSG/EASD Symposium, Prague, 2016. Oral.
• Khan TA, et al. Total Sugars, Fructose-Containing Sugars and CVD Risk. ASN/EB, San Diego, 2016. Poster.
• Khan TA, et al. Association of waist circumference and physical activity on arterial stiffness. ACC, Washington DC, 2014. Poster.
• Khan TA, et al. Lipoprotein(a): An investigation into causal mechanism of CHD risk. EAS Satellite Meeting, Copenhagen, 2011. Oral.
• Khan TA, et al. Lipoprotein(a): causal mechanism of CHD risk. Conference on Genetics of Complex Diseases, London, 2011. Oral.
• Khan TA, et al. APOE Genotype and ischaemic stroke. 78th EAS Conference, Hamburg, Germany. Oral.
• Khan TA, et al. APOE Genotype and ischaemic stroke. EAS Summer School, Cambridge, UK, 2009. Oral.

Selected media

• VOI Breakfast show — Honey and its healing properties. Oct 2025.
• Newswise Live Event: Do No-Calorie Sweeteners Affect Health? Feb 2023.
• Medscape — Do Artificial Sweeteners Alter Post-Meal Glucose, Hunger Hormones? Mar 2023.
• Fox News — Honey as an alternative to sugar? Jan 2022.
• India TV News — Honey intake and blood sugar/cholesterol. Dec 2022.
• Evening Standard — Raw honey could help reduce blood sugar and cholesterol. Nov 2022.
• Metro — Honey is good for your heart and metabolism. Nov 2022.
• Geo News — Study shows miraculous health benefits of honey. Nov 2022.
• University of Toronto Media — Study suggests honey reduces cardiometabolic risks. Nov 2022.
• New York Times — Where You Carry Body Fat May Affect How Long You Live. Oct 2020.

Public understanding of science

Regular contributor to public understanding of science through talks, radio interviews, and magazine articles for The Review of Religions, Al-Hakam Weekly, and Voice of Islam. Topics include the science of honey, diet and health, and Quranic inspiration for research (2015–present).

Teaching

• Advanced Meta-analysis Using STATA2019–Present
  Meta-Analysis in Nutrition Study Group, University of Toronto
• Introduction to Meta-analysis Using STATA2018–2019
  Risk Factor Modification Centre Seminar Series, St Michael's Hospital
• Course Organizer, EPM307 Global Epidemiology of NCDs2013–2018
  MSc Epidemiology (Distance Learning), LSHTM. Led the effort to revise and upgrade the course in 2017–18.
• Course Instructor, Introduction to Epidemiology (FIPH705)2011
  MSc Public Health Nutrition, University of Westminster, UK
• Course Instructor (4 modules)2007–2019
  MSc Clinical Trials & MSc Epidemiology (Distance Learning), LSHTM
  CTM104 Reporting & Reviewing Clinical Trials · CTM201 Protocol Development · CTM207 Design & Analysis of Epi Studies · CTM210 Integrating Module · EPM105 Writing & Reviewing Epi Papers · EPM303 Epidemiology of NCDs · EPM307 Global Epidemiology of NCDs
• Course Instructor, Advanced Methods in Epidemiological Analysis2008–2012
  Summer Course (in-person), LSHTM
  Modules: disease frequency, confounding and interaction, cohort/case-control analysis, logistic/Poisson regression, survival analysis, cluster data analysis
• Course Instructor, Intensive Course in Epidemiology2008–2012
  In-person course, LSHTM
  Covers: measuring health/disease, study design, statistical inference, regression analysis, systematic review and meta-analysis

Supervision and mentoring

As Senior Research Associate, I have supervised, mentored and taught students in the Sievenpiper laboratory at the University of Toronto. Students under my supervision have won numerous competitive awards (CGS-M, BBDC fellowships, Toronto 3D scholarships, travel awards).

Visiting scientist

• Stefan Kabisch, MD, PhDJan–Jun 2020
  Knowledge syntheses of diet and cardiometabolic risk for guidelines development

Phd students

• Michelle NguyenFeb 2022–present
  Sugary beverage consumption and cardiometabolic risk
• Sabrina Ayoub-CharetteSep 2018–present
  Non-nutritive sweeteners on microbiome in STOP SUGARS NOW trial
• Fei (Rodney) Au-Yeung, MScSep 2016–present
  Meta-analyses of food sources of sugars and CVD

Visiting phd

• Nerea Becerra-Tomás (Universitat Rovira i Virgili, Spain)Mar–Jun 2017
  Mediterranean diet and CVD in diabetes

Msc students

• Victoria ChenSep 2022–present
  Low-risk lifestyle behaviours and mortality
• Amna AhmedSep 2020–present
  Rare sugars in honey and cardiometabolic risk
• Danielle LeeSep 2019–Sep 2021
  Food sources of sugars and ectopic fat
• Annette CheungSep 2018–Sep 2020
  Food sources of sugars and body weight
• Néma McGlynnJan 2018–May 2020
  Non-nutritive sweeteners on glucose tolerance in STOP SUGARS NOW
• Neshat DeljoomaneshSep 2016–Sep 2017
  Genetic variation in fructokinase and metabolic syndrome
• Catherine BraunsteinSep 2015–Sep 2017
  Acute catalytic effects of fructose and allulose
• Jarvis NoronhaSep 2015–Sep 2017
  Acute catalytic effects of fructose and allulose in diabetes

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Peer review

Regular reviewer for: American Journal of Clinical Nutrition, BMJ, Applied Physiology Nutrition and Metabolism, Atherosclerosis, BMC Nutrition, Clinical Obesity, European Journal of Nutrition, European Journal of Clinical Nutrition, Food Science and Nutrition, Nutrients, Nutrition Journal, Obesity, PLoS One, PLoS Medicine.

Paid review: Systematic Review and Meta-Analysis: Stepwise Medical Research — Elsevier Books (2022).

Skills

• Statistical Software: Extensive experience with STATA (pairwise, network, dose-response meta-analysis; linear, logistic, mixed models) and R
• Computing: Endnote, Zotero, MS Office, macOS
• AI-Assisted Research: Claude Code (Anthropic) for research productivity under human oversight — PDF data extraction, systematic review and meta-analysis workflows, reproducible Stata/R pipelines, figure generation, and manuscript preparation; all outputs reviewed and validated by the investigator

Memberships

• Canadian Nutrition Society (since 2018)
• American Society of Nutrition (since 2018)
• Canadian Society of Endocrinology and Metabolism (since 2019)

Volunteer and community service

• National Director of Education (National Secretary Talim)2022–Present
  Ahmadiyya Muslim Community Canada
• Outreach and Education Secretary2021–2022
  Ahmadiyya Muslim Community, Milton
• Judgement Coordinator, Abdus Salam Science Fair (GTA)2016–2022
• Judge, 3-Minute Thesis Competition2016–2019
• Editor, Science Section, The Review of Religions2015–Present
  Comparative religious magazine presenting teachings from scientific, historical, and archaeological perspectives
• Chairman, Review of Religions Research Group Canada2015–2019
• Editor, Tariq Magazine for Youth, AMYA UK2010–2014
• Director of Student Affairs, AMYA UK2010–2014
  Organized career seminars, lectures, and mentorship for students
• Founding Member, Ahmadi Cycling Club (ACC) UK & Canada2012–Present
  Avid road cyclist (~100 km/week)
• Head, Ahmadiyya Muslim Research Association, UK2008–2010

Disclosures

TAK discloses receiving research grants from Diabetes Canada, CIHR, IAFNS (formerly ILSI North America), National Honey Board (USDA Checkoff), and the Toronto 3D Foundation. TAK has received honoraria from IAFNS, IFIC, Calorie Control Council, International Sweeteners Association, AmCham Dubai, and Ontario Maple Syrup Producers' Association. TAK has served as a consultant for Heartland Foods Product Group.